4-Tolylboronic acid pinacol ester

4-Tolylboronic acid pinacol ester - Names and Identifiers

Name	4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-Yl)toluene
Synonyms	Bm017 4-Tolylboronic acid pinacol ester 4-Biphenylboronic acid pinacol ester 4-Methylphentlboronic acid pinacol ester 4-methylphenylboronic acid, pinacol ester 4-METHYLPHENYLBORONIC ACID, PINACOL ESTER 4-Methylbenzeneboronic acid, pinacol ester 4,4,5,5-tetramethyl-2-p-tolyl-1,3,2-dioxaborolane 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-Yl)toluene 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)TOLUENE 2-(4-Methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 4,4,5,5-tetramethyl-2-(4-methylphenyl)-1,3,2-dioxaborolane
CAS	195062-57-8

4-Tolylboronic acid pinacol ester - Physico-chemical Properties

Molecular Formula	C13H19BO2
Molar Mass	218.1
Density	0.98±0.1 g/cm3(Predicted)
Melting Point	53.3-54.0°C
Boling Point	298.2±19.0 °C(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
MDL	MFCD07368291
Use	Pharmaceutical intermediates; Liquid crystals

4-Tolylboronic acid pinacol ester - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

4-Tolylboronic acid pinacol ester - Upstream Downstream Industry

Raw Materials

3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)toluene
BENZYLBORONIC ACID PINACOL ESTER
2-METHYLPHENYLBORONIC ACID, PINACOL ESTER
Toluene
Pinacolborane
Bis(pinacolato)diboron

4-Tolylboronic acid pinacol ester - Introduction

4-(4,4,5,5-tetramethyl-1, 3,2-dioxaborolan-2-yl) toluene is an organic compound with the chemical formula C8H11BO2. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: 4-(4,4,5,5-tetramethyl-1, 3,2-dioxaborolan-2-yl) toluene is a colorless to pale yellow liquid.
-Solubility: It can be dissolved in organic solvents, such as ethanol, ether and dimethylformamide.
-Stability: It is a stable compound that is not easy to decompose at room temperature.

Use:
- 4-(4,4,5,5-tetramethyl-1, 3,2-dioxaborolan-2-yl) toluene is commonly used as a catalyst for organic synthesis reactions, especially in the synthesis of alcohols and ethers.
-It can also be used for B- N bond formation reactions in organic synthesis.

Method:
The preparation of 4-(4,4,5,5-tetramethyl-1, 3,2-dioxaborolan-2-yl) toluene can be achieved by the following steps:
1. P-Toluene boric acid is obtained by heating and reacting p-Toluene ether (p-xylene) with boric acid.
2. Heat and react the obtained P-toluene boronic acid with pynalol to generate 4-(4,4,5,5-tetramethyl-1, 3,2-dioxaborolan-2-yl) toluene.

Safety Information:
- 4-(4,4,5,5-tetramethyl-1, 3,2-dioxaborolan-2-yl) toluene is less toxic, but still requires careful handling.
-Avoid contact with eyes, skin and use.
-Avoid open flames and high temperature conditions during use and storage.
-As a chemical, it should be stored properly, away from fire and flammable substances, and maintain a well-ventilated environment.
-When using this compound, follow proper laboratory safety procedures and wear appropriate personal protective equipment, such as lab gloves, protective glasses and lab clothes. In the event of an accident, immediately rinse the contaminated area with clean water and seek medical help.

Last Update：2024-04-10 22:29:15